Issue 3, 2024

DNA nanotechnology-based nucleic acid delivery systems for bioimaging and disease treatment

Abstract

Nucleic acids, including DNA and RNA, have been considered as powerful and functional biomaterials owing to their programmable structure, good biocompatibility, and ease of synthesis. However, traditional nucleic acid-based probes have always suffered from inherent limitations, including restricted cell internalization efficiency and structural instability. In recent years, DNA nanotechnology has shown great promise for the applications of bioimaging and drug delivery. The attractive superiorities of DNA nanostructures, such as precise geometries, spatial addressability, and improved biostability, have enabled them to be a novel category of nucleic acid delivery systems for biomedical applications. In this review, we introduce the development of DNA nanotechnology, and highlight recent advances of DNA nanostructure-based delivery systems for cellular imaging and therapeutic applications. Finally, we propose the challenges as well as opportunities for the future development of DNA nanotechnology in biomedical research.

Graphical abstract: DNA nanotechnology-based nucleic acid delivery systems for bioimaging and disease treatment

Article information

Article type
Minireview
Submitted
28 Okt. 2023
Accepted
21 Dec. 2023
First published
23 Dec. 2023

Analyst, 2024,149, 599-613

DNA nanotechnology-based nucleic acid delivery systems for bioimaging and disease treatment

Z. Sun, Y. Ren, W. Zhu, Y. Xiao and H. Wu, Analyst, 2024, 149, 599 DOI: 10.1039/D3AN01871G

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