Issue 21, 2023

Direct C(sp2)–H fluoroalkylation of quinoxalin-2(1H)-ones with (fluoroalkyl)triphenylphosphonium salts and alkenes

Abstract

A photoredox-catalyzed direct C(sp2)–H fluoroalkylation of quinoxalin-2(1H)-ones with (fluoroalkyl)triphenylphosphonium salts and alkenes is described, providing a practical approach for the generation of diverse fluoroalkyl-containing quinoxalin-2(1H)-ones. This methodology exhibits good reaction efficiency, excellent functional group tolerance and extensive structural diversity. In this transformation, difluoromethyl and monofluoroalkyl triphenylphosphonium salts are used as the precursors for providing the corresponding fluoroalkyl radicals via a single electron transfer process under photoredox catalysis.

Graphical abstract: Direct C(sp2)–H fluoroalkylation of quinoxalin-2(1H)-ones with (fluoroalkyl)triphenylphosphonium salts and alkenes

Supplementary files

Article information

Article type
Research Article
Submitted
06 Aug. 2023
Accepted
15 Sept. 2023
First published
15 Sept. 2023

Org. Chem. Front., 2023,10, 5375-5382

Direct C(sp2)–H fluoroalkylation of quinoxalin-2(1H)-ones with (fluoroalkyl)triphenylphosphonium salts and alkenes

W. Wang, T. Zhu and J. Wu, Org. Chem. Front., 2023, 10, 5375 DOI: 10.1039/D3QO01247F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements