Issue 6, 2023

Photocatalytic dehydrations for the Ritter reaction

Abstract

The Ritter reaction is a powerful method for the synthesis of amides; however, the photoinduced Ritter reaction of alcohols is rarely reported. We herein report a simple and additive-free photocatalytic dehydration method for the efficient direct conversion of benzyl alcohols to the corresponding amides using an organic photocatalyst 2,4,6-triphenylpyrylium salt. Experimental and computational mechanistic analyses show that a non-conventional generation process of a carbocation is involved in this photoinduced Ritter reaction.

Graphical abstract: Photocatalytic dehydrations for the Ritter reaction

Supplementary files

Article information

Article type
Research Article
Submitted
28 Dec. 2022
Accepted
09 Febr. 2023
First published
11 Febr. 2023

Org. Chem. Front., 2023,10, 1375-1379

Photocatalytic dehydrations for the Ritter reaction

L. Bao, B. Zhang, Z. Wang and X. Chen, Org. Chem. Front., 2023, 10, 1375 DOI: 10.1039/D2QO02046G

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