Issue 6, 2023

Selenylated indoles: synthesis, effects on lipid membrane properties and DNA cleavage

Abstract

In this report, we evaluated the effects of selenylated indoles (3a–d) on lipid membranes and their capacity to interact with DNA. These selenylated indoles increased the motion rate of the polar region of lipids and compounds 3b–d ordered the non-polar region. The DNA cleavage ability was observed only for 3c.

Graphical abstract: Selenylated indoles: synthesis, effects on lipid membrane properties and DNA cleavage

Supplementary files

Article information

Article type
Paper
Submitted
30 Aug. 2022
Accepted
12 Dec. 2022
First published
13 Dec. 2022

New J. Chem., 2023,47, 2719-2726

Selenylated indoles: synthesis, effects on lipid membrane properties and DNA cleavage

G. J. Pedroso, D. M. S. Costa, L. T. Felipe Kokuszi, E. B. V. da Silva, M. F. O. Cavalcante, E. Junca, C. A. O. Moraes, C. T. Pich, V. R. de Lima, S. Saba, J. Rafique and T. E. A. Frizon, New J. Chem., 2023, 47, 2719 DOI: 10.1039/D2NJ04330K

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