Issue 23, 2023

Electrochemical-induced solvent-tuned selective transfer hydrogenation of imidazopyridines with carbazates as hydrogen donors

Abstract

A solvent-tuned electrochemical protocol for the selective transfer hydrogenation of imidazopyridines using carbazates as hydrogen donors has been developed. This electrosynthesis strategy provides a more sustainable and greener way to access partially saturated N-heterocycles by avoiding traditionally employed transition metal catalysts and high-pressure hydrogen. Remarkably, the method is scalable and applicable to late-stage functionalization of complex molecules. A possible mechanism has been proposed on the basis of radical-trapping and cyclic voltammetry experiments.

Graphical abstract: Electrochemical-induced solvent-tuned selective transfer hydrogenation of imidazopyridines with carbazates as hydrogen donors

Supplementary files

Article information

Article type
Paper
Submitted
07 Sept. 2023
Accepted
20 Okt. 2023
First published
23 Okt. 2023

Green Chem., 2023,25, 9705-9710

Electrochemical-induced solvent-tuned selective transfer hydrogenation of imidazopyridines with carbazates as hydrogen donors

Z. Tang, G. Hong, J. Chen, T. Huang, Z. Zhou and L. Wang, Green Chem., 2023, 25, 9705 DOI: 10.1039/D3GC03389A

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