Issue 67, 2023

Mitochondrial NIR imaging probe mitigating oxidative damage by targeting HDAC6

Abstract

Despite the apparent copious fluorescent probes targeting mitochondria, the development of low cytotoxic probes is still needed for improving validation of mitochondrial function assessment. Herein, we report a novel cyanine-based NIR fluorescent probe, T2, which selectively targets mitochondria with significantly low toxicity by modulating the intracellular redox status. Additionally, T2 inhibits oxidative stress-induced cell death in cortical neurons. This study provides new insight into developing low-toxic mitochondrial imaging agents by regulating redox homeostasis.

Graphical abstract: Mitochondrial NIR imaging probe mitigating oxidative damage by targeting HDAC6

Supplementary files

Article information

Article type
Communication
Submitted
06 Jūl. 2023
Accepted
24 Jūl. 2023
First published
25 Jūl. 2023

Chem. Commun., 2023,59, 10109-10112

Mitochondrial NIR imaging probe mitigating oxidative damage by targeting HDAC6

J. Kim, P. Jangili, J. Kim, S. E. Lucia, J. R. Ryu, R. Prasad, S. Zi, P. Kim, W. Sun and J. S. Kim, Chem. Commun., 2023, 59, 10109 DOI: 10.1039/D3CC03259K

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