Issue 41, 2023

DNA-encoded libraries via late-stage functionalization strategies: a review

Abstract

The hit finding strategy in drug discovery has undergone a tremendous change in the past decade with the advent of DNA-encoded libraries with diverse chemical libraries. The miniaturization of the assays has enabled high-throughput screening on diverse targets to identify binders as a starting point for medicinal chemistry campaign. The diverse chemical space that can be accessed through DEL provides a unique opportunity to explore new chemistries on DNA. This review highlights the metal-mediated synthetic pathways that allow late-stage functionalisation of DNA strands to access such DEL libraries. Critical analysis of the literature and the methods employed has been done to allow readers to understand the usefulness, as well as the limitations of these protocols.

Graphical abstract: DNA-encoded libraries via late-stage functionalization strategies: a review

Article information

Article type
Highlight
Submitted
04 Marts 2023
Accepted
03 Apr. 2023
First published
03 Apr. 2023

Chem. Commun., 2023,59, 6128-6147

DNA-encoded libraries via late-stage functionalization strategies: a review

R. Sahu, S. Yadav, S. Nath, J. Banerjee and A. R. Kapdi, Chem. Commun., 2023, 59, 6128 DOI: 10.1039/D3CC01075A

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