Issue 17, 2023

Observing hydrogen sulfide in the endoplasmic reticulum of cancer cells and zebrafish by using an activity-based fluorescent probe

Abstract

A crucial endogenous signaling chemical, hydrogen sulfide, is involved in many physiological actions. In this work, we created the fluorescent probe ER-Nap-NBD using a naphthalimide fluorophore as the signal reporter, a 7-nitro-1,2,3-benzoxadiazole amine as the responsive moiety, and a sulfonamide part for endoplasmic reticulum targeting. ER-Nap-NBD could be detected the H2S levels in solution and in living systems (cells and zebrafish).

Graphical abstract: Observing hydrogen sulfide in the endoplasmic reticulum of cancer cells and zebrafish by using an activity-based fluorescent probe

Supplementary files

Article information

Article type
Communication
Submitted
06 Dec. 2022
Accepted
31 Janv. 2023
First published
04 Febr. 2023

Chem. Commun., 2023,59, 2493-2496

Observing hydrogen sulfide in the endoplasmic reticulum of cancer cells and zebrafish by using an activity-based fluorescent probe

Y. S. Kafuti, S. Zeng, X. Liu, J. Han, M. Qian, Q. Chen, J. Wang, X. Peng, J. Yoon and H. Li, Chem. Commun., 2023, 59, 2493 DOI: 10.1039/D2CC06645A

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