Issue 14, 2023

Structural and componential design: new strategies regulating the behavior of lipid-based nanoparticles in vivo

Abstract

Lipid-based nanoparticles have made a breakthrough in clinical disease as delivery systems due to their biocompatibility, thermal and long-term stability, high loading ability, simplicity of preparation, inexpensive production costs, and scalable manufacturing production. In particular, during the COVID-19 pandemic, this delivery system served as a vital vaccine component for virus confrontation. To obtain effective drug delivery, lipid-based nanoparticles should reach the desired sites with high efficiency, enter target cells, and release drugs. The structures and compositions of lipid-based nanoparticles can be modified to regulate these behaviors in vivo to enhance the therapeutic effects. Herein, we briefly review the development of lipid-based nanoparticles, from simple self-assembled nanovesicle-structured liposomes to multifunctional lipid nanoparticles. Subsequently, we summarize the strategies that regulate their tissue distribution, cell internalization, and drug release, highlighting the importance of the structural and componential design. We conclude with insights for further research to advance lipid-based nanotechnology.

Graphical abstract: Structural and componential design: new strategies regulating the behavior of lipid-based nanoparticles in vivo

Article information

Article type
Review Article
Submitted
04 Marts 2023
Accepted
14 Maijs 2023
First published
15 Maijs 2023

Biomater. Sci., 2023,11, 4774-4788

Structural and componential design: new strategies regulating the behavior of lipid-based nanoparticles in vivo

Q. Zhong, C. Zheng, K. Yi, R. L. Mintz, S. Lv, Y. Tao and M. Li, Biomater. Sci., 2023, 11, 4774 DOI: 10.1039/D3BM00387F

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