Issue 12, 2023

A chitosan-based self-healing hydrogel for accelerating infected wound healing

Abstract

Wound infection causes irregular tissue closure, often with prolonged healing. Traditional therapies based on antibiotic delivery have resulted in reduced therapeutic efficiency and drug resistance. Such features make it highly desirable to develop an antibiotic-free material for wound infection in clinical applications. Herein, a self-healing antibacterial hydrogel was designed to realize the treatment of S. aureus-infected wounds. The design of the dynamic imine bond endows hydrogels with self-healing and adaptive properties, which could cover the irregular wound and improve the safety of administration. In addition, benefiting from quaternized chitosan, the designed hydrogels also present fascinating antimicrobial properties and favorable biocompatibility. The evaluation in a rat skin wound infection model indicates that the fascinating antimicrobial effect accelerates wound healing by the designed hydrogels. This facile design of an antibiotic-free material allows effective wound infection management, which may be promising in coping with other complex wound healings.

Graphical abstract: A chitosan-based self-healing hydrogel for accelerating infected wound healing

Supplementary files

Article information

Article type
Paper
Submitted
13 Janv. 2023
Accepted
23 Febr. 2023
First published
23 Febr. 2023

Biomater. Sci., 2023,11, 4226-4237

A chitosan-based self-healing hydrogel for accelerating infected wound healing

H. Cui, B. Cui, H. Chen, X. Geng, X. Geng, Z. Li, S. Cao, J. Shen and J. Li, Biomater. Sci., 2023, 11, 4226 DOI: 10.1039/D3BM00061C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements