Issue 4, 2023

Vitamin D metabolites and analytical challenges

Abstract

Vitamin D is an essential micronutrient for bone health and the general cellular functions of the body. Its insufficiency/deficiency leads to the pathophysiology of disorders like diabetes, cancer, autoimmune, neurodegenerative, and cardiovascular diseases. Clinical interest in Vitamin D metabolites and their role in various medical disorders have contributed to an increase in laboratory demands for vitamin D measurements. For clinical and research laboratories worldwide, analysis of vitamin D and associated metabolites is a significant problem. The best way for determining vitamin D levels is constantly being debated. Various methods such as immunoassays and chromatographic techniques are available for determining vitamin D levels. Additionally, biosensors have recently been considered promising options for routine vitamin D analysis. The existing methods and other developments in the measurement of vitamin D metabolites and associated analytical challenges are discussed in this review.

Graphical abstract: Vitamin D metabolites and analytical challenges

Article information

Article type
Critical Review
Submitted
17 Okt. 2022
Accepted
09 Dec. 2022
First published
12 Dec. 2022

Anal. Methods, 2023,15, 399-410

Vitamin D metabolites and analytical challenges

M. Naik, S. Kamath U, S. Uppangala, S. K. Adiga and A. Patil, Anal. Methods, 2023, 15, 399 DOI: 10.1039/D2AY01692C

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