Issue 4, 2022

Recent advances in transition-metal-free trifluoromethylation with Togni's reagents

Abstract

Transition-metal-free trifluoromethylations have attracted significant research interest driven by the increasing importance of CF3-containing compounds. Among the various trifluoromethylation reagents, Togni's reagents exhibit exceptional reactivities, and many important organic transformations have been realized employing such reagents. This review describes several key activation methods for Togni's reagents under transition-metal-free conditions by showcasing selected cornerstone research areas and related mechanisms to stimulate the interest of readers in participating in the development of novel efficient transition-metal-free trifluoromethylations with Togni's reagents.

Graphical abstract: Recent advances in transition-metal-free trifluoromethylation with Togni's reagents

Article information

Article type
Review Article
Submitted
07 Okt. 2021
Accepted
14 Dec. 2021
First published
16 Dec. 2021

Org. Chem. Front., 2022,9, 1152-1164

Recent advances in transition-metal-free trifluoromethylation with Togni's reagents

J. Chen, J. Huang, K. Sun and W. He, Org. Chem. Front., 2022, 9, 1152 DOI: 10.1039/D1QO01504D

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