Issue 44, 2022

Ligand-regulated three-photon AIE properties of manganese(ii) complexes for photodynamic therapy

Abstract

Owing to the advantages of deeper penetration depth and lower biological damage, multi-photon AIE probes are widely used in the field of multi-photon therapy. We have developed a series of carbazole terpyridine manganese(II) complexes (MD1–MD3) that are promising as aggregation-induced emission (AIE) photosensitizers (PSs). MD1–MD3 exhibit excellent three-photon AIE properties in DMSO/H2O solution. We modulated the AIE properties of the Mn(II) complexes by introducing halogen atoms (Br/I). The three-photon fluorescence intensity of the complexes upon introducing halogen atoms is strong under the conditions of fw = 99% and 60%, respectively. Based on halogen-substituted carbazole ligands, MD3 can be applied as a multi-photon absorption photosensitizer which can produce 1O2 and O2˙. MD3 damages the mitochondrial morphology, leads to a decrease in mitochondrial membrane potential, and then triggers the apoptosis of cancer cells. Furthermore, MD3 is successfully applied as a photosensitizer in tumor theranostics in vivo. This work provides a new idea for ligand modulation of multiphoton AIE ground state transition metal complexes to make them multiphoton therapeutic agents.

Graphical abstract: Ligand-regulated three-photon AIE properties of manganese(ii) complexes for photodynamic therapy

Supplementary files

Article information

Article type
Paper
Submitted
25 Jūl. 2022
Accepted
17 Okt. 2022
First published
19 Okt. 2022

Dalton Trans., 2022,51, 16915-16920

Ligand-regulated three-photon AIE properties of manganese(II) complexes for photodynamic therapy

L. Liu, T. Zhu, C. Cai, L. Wang, S. Li, X. Lian, Y. Feng, Y. Tian and Q. Zhang, Dalton Trans., 2022, 51, 16915 DOI: 10.1039/D2DT02410A

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