Issue 71, 2022

Amide bond hydrolysis of peptoids

Abstract

Incorporating a chiral non-coordinating substitution at the N-terminal end within peptoids facilitates regio-selective amide bond hydrolysis mediated by a transition metal ion and/or an acidic buffer as evident by X-ray crystallographic analysis, supported by ESI-MS. This opens up a new direction for peptidomimetic compounds towards future application in chemistry, biology and medicine.

Graphical abstract: Amide bond hydrolysis of peptoids

Supplementary files

Article information

Article type
Communication
Submitted
13 Maijs 2022
Accepted
02 Aug. 2022
First published
02 Aug. 2022

Chem. Commun., 2022,58, 9922-9925

Amide bond hydrolysis of peptoids

P. Ghosh, G. Ruan, N. Fridman and G. Maayan, Chem. Commun., 2022, 58, 9922 DOI: 10.1039/D2CC02717H

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