Issue 19, 2022

semiaza-Bambusurils are anion-specific transmembrane transporters

Abstract

semiaza-Bambus[6]urils efficiently transport anions across lipid membranes. A systematic modification of their lipophilic side chains to include various alkyl groups and thioethers reveals that the most efficient chloride transporters are those that agree with Lipinski's rule-of-lipophilicity, exhibiting clog Po/w values close to 5. Furthermore, vesicle anion-transport assays show that the new anion-transporters are independent of the cation identity but exhibit high anion selectivity, NO3 > Br > Cl > SO42−, in agreement with the Hofmeister series. These findings will allow for the design of highly specific anion transporters for biomedical applications, particularly for managing anion channelopathies.

Graphical abstract: semiaza-Bambusurils are anion-specific transmembrane transporters

Supplementary files

Article information

Article type
Communication
Submitted
08 Janv. 2022
Accepted
08 Febr. 2022
First published
08 Febr. 2022

Chem. Commun., 2022,58, 3150-3153

semiaza-Bambusurils are anion-specific transmembrane transporters

R. Khurana, F. Yang, R. Khurana, J. Liu, E. Keinan and O. Reany, Chem. Commun., 2022, 58, 3150 DOI: 10.1039/D2CC00144F

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