Issue 11, 2022

Non-destructive molecular FTIR spectromicroscopy for real time assessment of redox metallodrugs

Abstract

Recent emergence of FTIR spectromicroscopy (micro-FTIR) as a dynamic spectroscopy for imaging to study biological chemistry has opened new possibilities for investigating in situ drug release, redox chemistry effects on biological molecules, DNA and drug interactions, membrane dynamics, and redox reactions with proteins at the single cell level. Micro-FTIR applied to metallodrugs has been playing an important role since the last decade because of its great potential to achieve more robust and controlled pharmacological effects against several diseases, including cancer. An important aspect in the development of these drugs is to understand their cellular properties, such as uptake, accumulation, activity, and toxicity. In this review, we present the potential application of micro-FTIR and its importance for studying metal-based drugs, highlighting the perspectives of chemistry of living cells. We also emphasise bioimaging, which is of high importance to localize the cellular processes, for a proper understanding of the mechanism of action.

Graphical abstract: Non-destructive molecular FTIR spectromicroscopy for real time assessment of redox metallodrugs

Article information

Article type
Minireview
Submitted
14 Jūl. 2021
Accepted
30 Nov. 2021
First published
01 Dec. 2021

Anal. Methods, 2022,14, 1094-1102

Non-destructive molecular FTIR spectromicroscopy for real time assessment of redox metallodrugs

L. J. A. Macedo, F. P. Rodrigues, A. Hassan, L. N. C. Máximo, F. Zobi, R. S. da Silva and F. N. Crespilho, Anal. Methods, 2022, 14, 1094 DOI: 10.1039/D1AY01198G

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