Issue 45, 2021

Facile synthesis of near-infrared bodipy by donor engineering for in vivo tumor targeted dual-modal imaging

Abstract

Bodipy is one of the most popular dyes for bioimaging, however, a complicated synthetic protocol is needed to create and isolate ideal near-infrared (NIR) emissive Bodipy derivatives for optical bioimaging. It is noticed that the donor species impact the wavelength when the π-conjugation system of green light emissive Bodipy is elongated via a one-step reaction. Herein, several Bodipy dyes bearing different common donors are synthesized. Their optical properties confirm that both absorption and emission peaks of the synthesized Bodipy could be tuned to NIR wavelength by using stronger donors via a facile reaction. The synthesized monocarboxyl Bodipy could conjugate with aminated PEG to yield an amphiphilic polymer, which further self-assembles into a NIR nanoparticle (NP). The NIR NP exhibits preferential tumor accumulation via the enhanced permeation and retention (EPR) effect, making it useful for tumor diagnosis by both fluorescence imaging and photoacoustic tomography.

Graphical abstract: Facile synthesis of near-infrared bodipy by donor engineering for in vivo tumor targeted dual-modal imaging

Associated articles

Supplementary files

Article information

Article type
Paper
Submitted
30 Aug. 2021
Accepted
23 Okt. 2021
First published
25 Okt. 2021

J. Mater. Chem. B, 2021,9, 9308-9315

Facile synthesis of near-infrared bodipy by donor engineering for in vivo tumor targeted dual-modal imaging

F. An, J. Xin, C. Deng, X. Tan, O. Aras, N. Chen, X. Zhang and R. Ting, J. Mater. Chem. B, 2021, 9, 9308 DOI: 10.1039/D1TB01883C

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