Issue 36, 2021

Vascular transplantation with dual-biofunctional ePTFE vascular grafts in a porcine model

Abstract

Cardiovascular disease (CVD) poses serious health concerns worldwide. The lack of transplantable vascular grafts is an unmet clinical need in the surgical treatment of CVD. Although expanded polytetrafluoroethylene (ePTFE) vascular grafts have been used in clinical practice, a low long-term patency rate in small-diameter transplantation application is still the biggest challenge. Thus, surface modification of ePTFE is sought after. In this study, polydopamine (PDA) was used to improve the hydrophilia and provide immobilization sites in ePTFE. Bivalirudin (BVLD), a direct thrombin inhibitor, was used to enhance the anti-thrombotic activity of ePTFE. The peptides derived from extracellular matrix proteins were used to elevate the bioactivity of ePTFE. The morphology, chemical composition, peptide modified strength, wettability, and hemocompatibility of modified ePTFE vascular grafts were investigated. Then, an endothelial cell proliferation assay was used to evaluate the best co-modification strategy of the ePTFE vascular graft in vitro. Since a large animal could relatively better mimic human physiology, we chose a porcine carotid artery replacement model in the current study. The results showed that the BVLD/REDV co-modified ePTFE vascular grafts had a satisfactory patency rate (66.7%) and a higher endothelial cell coverage ratio (70%) at 12 weeks after implantation. This may offer an opportunity to produce a multi-biofunctional ePTFE vascular graft, thereby yielding a potent product to meet the clinical needs.

Graphical abstract: Vascular transplantation with dual-biofunctional ePTFE vascular grafts in a porcine model

Supplementary files

Article information

Article type
Paper
Submitted
22 Jūn. 2021
Accepted
31 Jūl. 2021
First published
02 Aug. 2021

J. Mater. Chem. B, 2021,9, 7409-7422

Vascular transplantation with dual-biofunctional ePTFE vascular grafts in a porcine model

Z. Xing, S. Wu, C. Zhao, Y. Bai, D. Jin, M. Yin, H. Liu and Y. Fan, J. Mater. Chem. B, 2021, 9, 7409 DOI: 10.1039/D1TB01398J

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