Issue 16, 2021

Deuteration mechanistic studies of hydrogenase mimics

Abstract

Hydrogen production is key to carbon-free energy production and the use of hydrogenases is an excellent approach for this achievement since they produce hydrogen with extraordinary efficiencies. However, these enzymes have several shortcomings, which may be resolved using hydrogenase mimics. The design and synthesis of these mimics is a very active area of research, and the understanding of the mode of the action of mimics is particularly relevant to the future design of robust and productive catalysts. In this review, we discuss the role of isotopes (mainly deuterium) in disentangling key steps of the mechanisms of H2 activation by mimics of hydrogenases. Through selected examples, we focus on the key aspects of processes that, in many cases, have allowed a better understanding of the mode of action of the natural enzymes, making a valuable contribution to the design of more efficient complexes for the production of hydrogen.

Graphical abstract: Deuteration mechanistic studies of hydrogenase mimics

Article information

Article type
Review Article
Submitted
17 Apr. 2021
Accepted
10 Jūn. 2021
First published
10 Jūn. 2021

Inorg. Chem. Front., 2021,8, 3934-3950

Deuteration mechanistic studies of hydrogenase mimics

M. Gómez-Gallego and M. A. Sierra, Inorg. Chem. Front., 2021, 8, 3934 DOI: 10.1039/D1QI00505G

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