Issue 44, 2021

Gold-catalyzed oxidative cyclization of amide-alkynes: access to functionalized γ-lactams

Abstract

An efficient gold-catalyzed oxidative cyclization of amide-alkynes is developed. A series of functionalized γ-lactams are easily accessed by employing this strategy. The tandem reaction proceeds through alkyne oxidation, carbene/alkyne metathesis, and donor/donor carbene oxidation.

Graphical abstract: Gold-catalyzed oxidative cyclization of amide-alkynes: access to functionalized γ-lactams

Supplementary files

Article information

Article type
Paper
Submitted
17 Sept. 2021
Accepted
22 Okt. 2021
First published
22 Okt. 2021

Org. Biomol. Chem., 2021,19, 9688-9691

Gold-catalyzed oxidative cyclization of amide-alkynes: access to functionalized γ-lactams

Y. Zheng, T. Zhang and W. Shen, Org. Biomol. Chem., 2021, 19, 9688 DOI: 10.1039/D1OB01846A

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