Issue 43, 2021

Solitumergosterol A, a unique 6/6/6/6/5 steroid from the deep-sea-derived Penicillium solitum MCCC 3A00215

Abstract

A unique C30 steroid, solitumergosterol A (1), was isolated from the deep-sea-derived fungus Penicillium solitum MCCC 3A00215. The planar structure and relative configuration of 1 were established mainly on the basis of extensive analysis of its 1D and 2D NMR as well as HRESIMS data, while its absolute configuration was clarified by comparison of the experimental and theoretical ECD spectra. Noteworthily, 1 is a Diels–Alder adduct of a heterogeneous steroid bearing a 6/6/6/6/5 pentacyclic carbon skeleton. Solitumergosterol A (1) exhibited weak in vitro anti-tumor activity against MB231 cells by a RXRα-dependent mechanism.

Graphical abstract: Solitumergosterol A, a unique 6/6/6/6/5 steroid from the deep-sea-derived Penicillium solitum MCCC 3A00215

Supplementary files

Article information

Article type
Communication
Submitted
17 Jūl. 2021
Accepted
24 Aug. 2021
First published
24 Aug. 2021

Org. Biomol. Chem., 2021,19, 9369-9372

Solitumergosterol A, a unique 6/6/6/6/5 steroid from the deep-sea-derived Penicillium solitum MCCC 3A00215

Z. He, C. Xie, Y. Hao, L. Xu, C. Wang, M. Hu, S. Li, T. Zhong and X. Yang, Org. Biomol. Chem., 2021, 19, 9369 DOI: 10.1039/D1OB01392K

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