Issue 40, 2021

Periodic charge matching driven immobilization of gentamicin in nanoclays for stable and long-term antibacterial coating

Abstract

Matching of charge periodicity between a guest and a host enabled effective immobilization of highly water-soluble antibiotic drug, gentamicin C, in a bentonite clay by cation exchange. X-ray diffraction, infrared spectroscopy and CHNS analysis revealed the immobilization manner of gentamicin C, which was immobilized between bentonite layers via periodic charge–charge interaction with tilted arrangement, as a trication. Both gentamicin alone and a gentamicin/bentonite hybrid were coated onto a polyurethane substrate using water-borne polyurethane binder. The antibiotic character of both films was investigated as prepared or after immersion in phosphate-buffered saline till 5 days against E. coli and B. subtilis bacteria. It was clearly shown that the gentamicin/bentonite hybrid–coated film showed sustained antibacterial efficacy even after exposure to phosphate-buffered saline, while gentamicin only–coated film gradually lost its performance under the same condition.

Graphical abstract: Periodic charge matching driven immobilization of gentamicin in nanoclays for stable and long-term antibacterial coating

Article information

Article type
Paper
Submitted
31 Jūl. 2021
Accepted
06 Sept. 2021
First published
06 Sept. 2021

Dalton Trans., 2021,50, 14216-14222

Periodic charge matching driven immobilization of gentamicin in nanoclays for stable and long-term antibacterial coating

T. Yamaguchi, S. Ko, J. Jung, H. Kim and J. Oh, Dalton Trans., 2021, 50, 14216 DOI: 10.1039/D1DT02540F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements