Issue 40, 2021

Separation of a diastereomeric diol pair using the mechanical properties of crystals

Abstract

We report the separation of a (2S,3R/S)-3-ethyl-1-phenylhex-5-ene-2,3-diol (ephd) diastereomeric pair with visually indistinguishable acicular morphologies based on their mechanical responses, which is found to be more efficient than conventional separation methods. Furthermore, the molecular crystals of (2S,3R)-ephd show elastic deformation, while (2S,3S)-ephd fractures in a brittle manner under similar conditions.

Graphical abstract: Separation of a diastereomeric diol pair using the mechanical properties of crystals

Supplementary files

Article information

Article type
Communication
Submitted
09 Aug. 2021
Accepted
14 Sept. 2021
First published
15 Sept. 2021

CrystEngComm, 2021,23, 7056-7060

Separation of a diastereomeric diol pair using the mechanical properties of crystals

R. K. Gamidi, M. Dandawate, S. Tothadi, R. Choudhury, A. K. Nangia and D. S. Reddy, CrystEngComm, 2021, 23, 7056 DOI: 10.1039/D1CE01055G

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