Issue 82, 2021

Easy access to secondary and tertiary alcohols via metal-free and light mediated radical carbonyl allylation

Abstract

Here we report a strategy for carbonyl addition with unactivated alkenes using an organic photocatalyst on both aldehyde and ketone substrates. This protocol grants us a good alternative to the traditional Barbier–Grignard allylation that exhibits poor functional group tolerance. With this method the stoichiometric use of metals can be avoided, high atom economy can be achieved and fewer by-products are generated.

Graphical abstract: Easy access to secondary and tertiary alcohols via metal-free and light mediated radical carbonyl allylation

Supplementary files

Article information

Article type
Communication
Submitted
20 Aug. 2021
Accepted
22 Sept. 2021
First published
29 Sept. 2021

Chem. Commun., 2021,57, 10783-10786

Easy access to secondary and tertiary alcohols via metal-free and light mediated radical carbonyl allylation

B. R. P. Yip, K. B. Pal, J. D. Lin, Y. Xu, M. Das, J. Lee and X. Liu, Chem. Commun., 2021, 57, 10783 DOI: 10.1039/D1CC04585G

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