Issue 41, 2020
From the journal:

Organic & Biomolecular Chemistry

Total synthesis of thioamycolamide A via a biomimetic route†

Chengqian Pan,a   Takefumi Kuranaga*a  and  Hideaki Kakeya ORCID logo *a  

* Corresponding authors

a Department of System Chemotherapy and Molecular Sciences, Division of Bioinformatics and Chemical Genomics, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan
E-mail: tkuranaga@pharm.kyoto-u.ac.jp, scseigyo-hisyo@pharm.kyoto-u.ac.jp

Abstract

Thioamycolamide A is a biosynthetically unique cytotoxic cyclic microbial lipopeptide that bears a D-configured thiazoline, a thioether bridge, a fatty acid side chain, and a reduced C-terminus. Based on the biosynthetic insights, a concise total synthesis of thioamycolamide A was accomplished.

Graphical abstract: Total synthesis of thioamycolamide A via a biomimetic route

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/D0OB01942A
Article type
Communication
Submitted
22 Sept. 2020
Accepted
05 Okt. 2020
First published
08 Okt. 2020

Org. Biomol. Chem., 2020,18, 8366-8370

Permissions

Request permissions

Total synthesis of thioamycolamide A via a biomimetic route

C. Pan, T. Kuranaga and H. Kakeya, Org. Biomol. Chem., 2020, 18, 8366 DOI: 10.1039/D0OB01942A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements