Issue 31, 2020

Quantitative determination of mechanical stability in the novel coronavirus spike protein

Abstract

We report on the novel observation about the gain in nanomechanical stability of the SARS-CoV-2 (CoV2) spike (S) protein in comparison with SARS-CoV from 2002 (CoV1). Our findings have several biological implications in the subfamily of coronaviruses, as they suggest that the receptor binding domain (RBD) (∼200 amino acids) plays a fundamental role as a damping element of the massive viral particle's motion prior to cell-recognition, while also facilitating viral attachment, fusion and entry. The mechanical stability via pulling of the RBD is 250 pN and 200 pN for CoV2 and CoV1 respectively, and the additional stability observed for CoV2 (∼50 pN) might play a role in the increasing spread of COVID-19.

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein

Article information

Article type
Communication
Submitted
23 Maijs 2020
Accepted
22 Jūl. 2020
First published
23 Jūl. 2020

Nanoscale, 2020,12, 16409-16413

Author version available

Quantitative determination of mechanical stability in the novel coronavirus spike protein

R. A. Moreira, M. Chwastyk, J. L. Baker, H. V. Guzman and A. B. Poma, Nanoscale, 2020, 12, 16409 DOI: 10.1039/D0NR03969A

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