Issue 6, 2020

Optimization of hydrophobic nanoparticles to better target lipid rafts with molecular dynamics simulations

Abstract

Due to different interactions between lipids and proteins, a plasma membrane can segregate into different membrane domains. Among them, ordered functional membrane domains are defined as “lipid rafts”, which play key roles in many biological processes (e.g., signal transduction, endocytosis, etc.) in the cell. Hence, it will be of much biological significance to monitor and even regulate the dynamics of lipid rafts. In this work, we designed a ligand-modified spherical nanoparticle with coarse-grained molecular dynamics simulations, which can be encapsulated into the hydrophobic region of the lipid membrane and specifically target either raft or non-raft membrane domains. The preferred localization of the nanoparticle can be tuned by adjusting ligand hydrophobicity, length and density. Generally, more hydrophobic nanoparticles tend to target the raft domain, while less hydrophobic nanoparticles prefer the non-raft domain. Besides, ligand length and density jointly determine the exposure of nanoparticle cores and thus affect the roles of ligands in nanoparticles’ final localization. Our results may provide insights into the experimental design of functional nanoparticles, targeting the lipid raft and regulating its dynamics.

Graphical abstract: Optimization of hydrophobic nanoparticles to better target lipid rafts with molecular dynamics simulations

Associated articles

Supplementary files

Article information

Article type
Paper
Submitted
29 Okt. 2019
Accepted
10 Janv. 2020
First published
10 Janv. 2020

Nanoscale, 2020,12, 4101-4109

Optimization of hydrophobic nanoparticles to better target lipid rafts with molecular dynamics simulations

X. Lin, X. Lin and N. Gu, Nanoscale, 2020, 12, 4101 DOI: 10.1039/C9NR09226A

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