Issue 13, 2020

Engineering functional inorganic nanobiomaterials: controlling interactions between 2D-nanosheets and enzymes

Abstract

A better understanding of the enzyme-nanosheet interface is imperative for the design of functional, robust inorganic nanobiomaterials and biodevices, now more than ever, for use in a broad spectrum of applications. This feature article discusses recent advances in controlling the enzyme-nanosheet interface with regards to α-zirconium(IV) phosphate (α-ZrP), graphene oxide (GO), graphene, and MoS2 nanosheets. Specific focus will be placed on understanding the mechanisms with which these materials interact with enzymes and elaborate on particular ways to engineer and control these interactions. Our main discoveries include: (1) upon adsorption to the nanosheet surface, a decrease in the entropy of the enzyme's denatured state enhances stability; (2) proteins are used to create biophilic landing pads for increased enzyme stability on many different types of nanosheets; (3) proteins and enzymes are used as exfoliants by shear force to produce biofunctionalized nanosheet suspensions; and (4) bionfunctionalized nanosheets exhibit no acute toxicity. Recognizing proper methods to engineer the interface between enzymes and 2D-nanosheets, therefore, is an important step towards making green, sustainable, and environmentally conscious inorganic bionanomaterials for sensing, catalysis and drug delivery applications, as well as towards the successful manipulation of enzymes for advanced applications.

Graphical abstract: Engineering functional inorganic nanobiomaterials: controlling interactions between 2D-nanosheets and enzymes

Article information

Article type
Perspective
Submitted
01 Okt. 2019
Accepted
15 Nov. 2019
First published
04 Dec. 2019

Dalton Trans., 2020,49, 3917-3933

Engineering functional inorganic nanobiomaterials: controlling interactions between 2D-nanosheets and enzymes

M. K. Puglia, M. Malhotra and C. V. Kumar, Dalton Trans., 2020, 49, 3917 DOI: 10.1039/C9DT03893K

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