Issue 43, 2020

Structural similarity in chiral-achiral multi-component crystals

Abstract

The creation of multi-component crystals between chiral and achiral components has gained increased interest in recent years. In many cases the overall crystal structure is similar with the creation of a pseudo-inversion centre in the enantiopure case. This allows for the formation of solid solutions between the two extremes, which may have applications within chiral resolution. Utilising a combination of database mining, computational prediction and experimental screening, the frequency of formation for such materials has been investigated showing that for co-crystals this occurs more frequently than for salts, though there is a limited number of samples to draw structural conclusions. Computational modelling indicates the prediction of such systems can be challenging due to the similarities in energy of many crystal structures, so development of tools to design such systems is required to fully utilise these concepts.

Graphical abstract: Structural similarity in chiral-achiral multi-component crystals

Supplementary files

Article information

Article type
Paper
Submitted
28 Febr. 2020
Accepted
15 Apr. 2020
First published
15 Apr. 2020

CrystEngComm, 2020,22, 7334-7340

Structural similarity in chiral-achiral multi-component crystals

I. J. Scowen, T. S. Alomar, T. Munshi and C. C. Seaton, CrystEngComm, 2020, 22, 7334 DOI: 10.1039/D0CE00301H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements