Issue 37, 2019

The application of nanotechnology in enhancing immunotherapy for cancer treatment: current effects and perspective

Abstract

Cancer immunotherapy is emerging as a promising treatment modality that suppresses and eliminates tumors by re-activating and maintaining the tumor-immune cycle, and further enhancing the body's anti-tumor immune response. Despite the impressive therapeutic potential of immunotherapy approaches such as immune checkpoint inhibitors and tumor vaccines in pre-clinical and clinical applications, the effective response is limited by insufficient accumulation in tumor tissues and severe side-effects. Recent years have witnessed the rise of nanotechnology as a solution to improve these technical weaknesses due to its inherent biophysical properties and multifunctional modifying potential. In this review, we summarized and discussed the current status of nanoparticle-enhanced cancer immunotherapy strategies, including intensified delivery of tumor vaccines and immune adjuvants, immune checkpoint inhibitor vehicles, targeting capacity to tumor-draining lymph nodes and immune cells, triggered releasing and regulating specific tumor microenvironments, and adoptive cell therapy enhancement effects.

Graphical abstract: The application of nanotechnology in enhancing immunotherapy for cancer treatment: current effects and perspective

Article information

Article type
Review Article
Submitted
25 Jūn. 2019
Accepted
22 Aug. 2019
First published
22 Aug. 2019

Nanoscale, 2019,11, 17157-17178

The application of nanotechnology in enhancing immunotherapy for cancer treatment: current effects and perspective

Y. Li, C. Ayala-Orozco, P. R. Rauta and S. Krishnan, Nanoscale, 2019, 11, 17157 DOI: 10.1039/C9NR05371A

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