Issue 17, 2019

Lysosome-targeted carbon dots for ratiometric imaging of formaldehyde in living cells

Abstract

Formaldehyde (FA) is involved in many biological processes and is closely connected with many diseases including Alzheimer's disease and cancer. Therefore, methods for sensitive and selective detection of FA in living cells are highly demanded. As a new class of carbon nanomaterials, carbon dots (CDs) have attracted great attention owing to their robust photostability, good biocompatibility and environmental friendliness. In this manuscript, the first lysosome-targeted CDs for ratiometric fluorescence detection of FA were efficiently prepared from dexamethasone and 1,2,4,5-tetraaminobenzene through the microwave-assisted hydrothermal method. These CDs show highly selective and sensitive sensing ability towards FA with fast response and great changes of ratio values. The CDs exhibit robust photostability and good biocompatibility and were successfully employed in ratiometric fluorescence bioimaging of FA fluctuations in lysosomes of living cells, which demonstrates their great practicability in FA-related bioanalysis and biological studies.

Graphical abstract: Lysosome-targeted carbon dots for ratiometric imaging of formaldehyde in living cells

Supplementary files

Article information

Article type
Paper
Submitted
24 Febr. 2019
Accepted
03 Apr. 2019
First published
04 Apr. 2019

Nanoscale, 2019,11, 8458-8463

Lysosome-targeted carbon dots for ratiometric imaging of formaldehyde in living cells

H. Liu, Y. Sun, Z. Li, J. Yang, A. A. Aryee, L. Qu, D. Du and Y. Lin, Nanoscale, 2019, 11, 8458 DOI: 10.1039/C9NR01678C

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