Issue 14, 2019

Micro/nanomachines: what is needed for them to become a real force in cancer therapy?

Abstract

Conventional drug delivery systems face several issues in medical applications, such as cyto/genotoxicity and off-targeting. These issues are particularly significant for cancer therapeutics because many of the currently used systems are toxic in their free form. Self-propelled autonomous micro/nanomachines offer promising alternative drug delivery systems based on high cargo loading, fast autonomous movement, precise targeting and the on-demand release of therapeutics in vivo. With this unique set of properties, it is not surprising that they are receiving considerable research attention. However, much less is reported about the drawbacks that hinder their systemic in vivo application. In this review, a biomedical perspective is used to assess micro/nanomotor-based anticancer drug delivery systems reported to date. Advantages along with present issues are highlighted and recommendations which need to be considered to develop an effective biocompatible micro/nanomotor-based delivery system for cancer therapy are discussed.

Graphical abstract: Micro/nanomachines: what is needed for them to become a real force in cancer therapy?

Article information

Article type
Review Article
Submitted
02 Okt. 2018
Accepted
10 Dec. 2018
First published
11 Janv. 2019

Nanoscale, 2019,11, 6519-6532

Micro/nanomachines: what is needed for them to become a real force in cancer therapy?

L. Reinišová, S. Hermanová and M. Pumera, Nanoscale, 2019, 11, 6519 DOI: 10.1039/C8NR08022D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements