Issue 22, 2018

Mercaptopyrimidine-directed gold nanoclusters: a suitable fluorescent probe for intracellular glutathione imaging and selective cancer cell identification

Abstract

Herein, we demonstrate a novel, facile, and suitable strategy for imaging GSH based on mercaptopyrimidine-directed gold nanoclusters (Au NCs). GSH can specifically induce the fluorescence enhancement of Au NCs by attacking the surface of the NCs to form dual ligand stabilized Au NCs at the millimolar level. Very importantly, the Au NCs can selectively image cancer cells.

Graphical abstract: Mercaptopyrimidine-directed gold nanoclusters: a suitable fluorescent probe for intracellular glutathione imaging and selective cancer cell identification

Supplementary files

Article information

Article type
Communication
Submitted
23 Marts 2018
Accepted
16 Maijs 2018
First published
16 Maijs 2018

J. Mater. Chem. B, 2018,6, 3650-3654

Mercaptopyrimidine-directed gold nanoclusters: a suitable fluorescent probe for intracellular glutathione imaging and selective cancer cell identification

Y. Zheng, W. Liu, Y. Chen, H. Jiang and X. Wang, J. Mater. Chem. B, 2018, 6, 3650 DOI: 10.1039/C8TB00791H

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