Issue 17, 2018

A redox-responsive folate–fluorophore conjugate as a new target-cell-specific imaging probe

Abstract

Here we have developed a redox-responsive folate–fluorophore conjugate (RFC) with a disulfide linker for the target-specific imaging of cancers. The quenched fluorescence of the RFC could be turned on after folate receptor-mediated endocytosis and subsequent cleavage of the disulfide linker by intracellular glutathione, enabling target-cell-specific fluorescence imaging with a high target-to-background ratio.

Graphical abstract: A redox-responsive folate–fluorophore conjugate as a new target-cell-specific imaging probe

Supplementary files

Article information

Article type
Communication
Submitted
14 Aug. 2017
Accepted
26 Okt. 2017
First published
30 Okt. 2017

J. Mater. Chem. B, 2018,6, 2524-2527

A redox-responsive folate–fluorophore conjugate as a new target-cell-specific imaging probe

J. Kim, H. Kim and Y. Choi, J. Mater. Chem. B, 2018, 6, 2524 DOI: 10.1039/C7TB02180A

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