Issue 17, 2018

Metalla-aromatic loaded magnetic nanoparticles for MRI/photoacoustic imaging-guided cancer phototherapy

Abstract

In this study, metalla-aromatic agents (MA) and a cluster of superparamagnetic iron oxide nanoparticles (SPIOs) were loaded inside a micellar carrier (Alkyl-PEI2k-PEG), resulting in MA/SPIOs@Alkyl-PEI2k-PEG nanoparticles (MASAs). The prepared MASAs with a photothermal transduction efficiency of 26.6% were also demonstrated as a potential photodynamic sensitizer to generate ROS effectively. Under the guidance of MRI/photoacoustic imaging, combined photothermal and photodynamic therapy achieved a synergistic anti-tumor effect, significantly improving the therapeutic efficacy of MASAs both in vitro and in vivo. This work shows that the developed MASAs are a potential theranostic agent for dual-modal imaging-guided cancer phototherapy.

Graphical abstract: Metalla-aromatic loaded magnetic nanoparticles for MRI/photoacoustic imaging-guided cancer phototherapy

Supplementary files

Article information

Article type
Communication
Submitted
10 Aug. 2017
Accepted
26 Sept. 2017
First published
26 Sept. 2017

J. Mater. Chem. B, 2018,6, 2528-2535

Metalla-aromatic loaded magnetic nanoparticles for MRI/photoacoustic imaging-guided cancer phototherapy

C. Yang, G. Lin, C. Zhu, X. Pang, Y. Zhang, X. Wang, X. Li, B. Wang, H. Xia and G. Liu, J. Mater. Chem. B, 2018, 6, 2528 DOI: 10.1039/C7TB02145C

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