Issue 41, 2018

Peroxidase mimicking DNAzymes degrade graphene oxide

Abstract

DNAzymes made of supramolecular guanine-rich G-quadruplexes and hemin are attracting a lot of interest due to their peroxidase activity mimicking the natural enzyme horseradish peroxidase (HRP). Herein, we demonstrate that DNAzyme consisting of a PS2.M–hemin complex can be an alternative to natural HRP for the oxidation and degradation of graphene oxide (GO). The degradation of GO sheets was carried out by incubating the PS2.M–hemin complex in the presence of hydrogen peroxide for 30 days. The degradation of GO has been confirmed using transmission electron microscopy and 2d Raman mapping. The current study suggests that the peroxidase activity of DNAzymes is similar to HRP and DNAzymes are able to degrade carbon-based nanomaterials.

Graphical abstract: Peroxidase mimicking DNAzymes degrade graphene oxide

Supplementary files

Article information

Article type
Paper
Submitted
13 Aug. 2018
Accepted
14 Sept. 2018
First published
14 Sept. 2018

Nanoscale, 2018,10, 19316-19321

Peroxidase mimicking DNAzymes degrade graphene oxide

R. Kurapati and A. Bianco, Nanoscale, 2018, 10, 19316 DOI: 10.1039/C8NR06535G

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