Issue 18, 2017

N,S co-doped carbon dots as a stable bio-imaging probe for detection of intracellular temperature and tetracycline

Abstract

Stable bioimaging with nanomaterials in living cells has been a great challenge and of great importance for understanding intracellular events and elucidating various biological phenomena. Herein, we demonstrate that N,S co-doped carbon dots (N,S-CDs) produced by one-pot reflux treatment of C3N3S3 with ethane diamine at a relatively low temperature (80 °C) exhibit a high fluorescence quantum yield of about 30.4%, favorable biocompatibility, low-toxicity, strong resistance to photobleaching and good stability. The N,S-CDs as an effective temperature indicator exhibit good temperature-dependent fluorescence with a sensational linear response from 20 to 80 °C. In addition, the obtained N,S-CDs facilitate high selectivity detection of tetracycline (TC) with a detection limit as low as 3 × 10−10 M and a wide linear range from 1.39 × 10−5 to 1.39 × 10−9 M. More importantly, the N,S-CDs display an unambiguous bioimaging ability in the detection of intracellular temperature and TC with satisfactory results.

Graphical abstract: N,S co-doped carbon dots as a stable bio-imaging probe for detection of intracellular temperature and tetracycline

Supplementary files

Article information

Article type
Paper
Submitted
24 Marts 2017
Accepted
10 Apr. 2017
First published
11 Apr. 2017

J. Mater. Chem. B, 2017,5, 3293-3299

N,S co-doped carbon dots as a stable bio-imaging probe for detection of intracellular temperature and tetracycline

W. Shi, F. Guo, M. Han, S. Yuan, W. Guan, H. Li, H. Huang, Y. Liu and Z. Kang, J. Mater. Chem. B, 2017, 5, 3293 DOI: 10.1039/C7TB00810D

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