Issue 34, 2017

Poly(N-(2-hydroxypropyl)methacrylamide)–valproic acid conjugates as block copolymer nanocarriers

Abstract

We report nanoassemblies based on block copolymers of N-(2-hydroxypropyl)methacrylamide (HPMA) in which drug cleavage enhances the biological compatibility of the original polymer carrier by regeneration of HPMA units. Drug release via ester hydrolysis suggests this approach offers potential for stimuli-responsive drug delivery under acidic conditions.

Graphical abstract: Poly(N-(2-hydroxypropyl)methacrylamide)–valproic acid conjugates as block copolymer nanocarriers

Supplementary files

Article information

Article type
Communication
Submitted
02 Febr. 2017
Accepted
12 Febr. 2017
First published
22 Febr. 2017

Polym. Chem., 2017,8, 4983-4987

Poly(N-(2-hydroxypropyl)methacrylamide)–valproic acid conjugates as block copolymer nanocarriers

J. A. Alfurhood, H. Sun, C. P. Kabb, B. S. Tucker, J. H. Matthews, H. Luesch and B. S. Sumerlin, Polym. Chem., 2017, 8, 4983 DOI: 10.1039/C7PY00196G

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