Issue 17, 2017

Novel nanosensing technologies for exosome detection and profiling

Abstract

Exosomes have recently emerged as highly promising cancer biomarkers because they are abundant in biofluids, carry proteins and RNA reflecting their originating cells and are stable over weeks. Beyond abundance and stability, detailed exosome analyses could be clinically useful for diagnosing and profiling cancers. Despite their clinical potential, simple, reliable and sensitive approaches for rapidly quantifying exosomes and their molecular information has been challenging. Therefore, there is a clear need to develop next-generation sensing technologies for exosome detection and analysis. In this critical review, we will describe three nanotechnology sensing platforms developed for analysis of exosomal proteins and RNAs directly from clinical specimens and discuss future development to facilitate their translation into routine clinical use.

Graphical abstract: Novel nanosensing technologies for exosome detection and profiling

Article information

Article type
Critical Review
Submitted
07 Marts 2017
Accepted
18 Jūl. 2017
First published
18 Jūl. 2017

Lab Chip, 2017,17, 2892-2898

Novel nanosensing technologies for exosome detection and profiling

H. Im, K. Lee, R. Weissleder, H. Lee and C. M. Castro, Lab Chip, 2017, 17, 2892 DOI: 10.1039/C7LC00247E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements