Issue 4, 2017

Using titanium complexes to defeat cancer: the view from the shoulders of titans

Abstract

When the first titanium complex with anticancer activity was identified in the 1970s, it was attractive, based on the presence of the dichloride unit in TiCl2Cp2 (Cp = η-C5H5)2, to assume its mode of biological action was closely aligned with cisplatin [cis-PtCl2(NH3)2]. Over the intervening 40 years however a far more complicated picture has arisen indicating multiple cellular mechanisms of cellular action can be triggered by titanium anti-cancer agents. This tutorial review aims to unpick the historical data and provide new researchers, without an explicit cancer biology background, a contemporary interpretation of both older and newer literature and to review the best techniques for attaining the identities of the biologically active titanium species and how these interact with the cancer cellular machinery.

Graphical abstract: Using titanium complexes to defeat cancer: the view from the shoulders of titans

  • This article is part of the themed collection: Primer

Supplementary files

Article information

Article type
Tutorial Review
Submitted
01 Dec. 2016
First published
26 Janv. 2017

Chem. Soc. Rev., 2017,46, 1040-1051

Author version available

Using titanium complexes to defeat cancer: the view from the shoulders of titans

M. Cini, T. D. Bradshaw and S. Woodward, Chem. Soc. Rev., 2017, 46, 1040 DOI: 10.1039/C6CS00860G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements