Issue 22, 2017

Generation of cocrystals of Tavaborole (AN2690): opportunities for boron-containing APIs

Abstract

Cocrystals of the FDA-approved boron-containing API Tavaborole (AN2690) were obtained through solvent evaporation with coformers functionalized with 4-pyridyl groups. The components form three- and four-component supramolecular assemblies sustained by a combination of (B)OH⋯Npyr hydrogen bonds and C–H⋯F interactions, as demonstrated by single-crystal X-ray diffraction analysis. Three cocrystals are isostructural.

Graphical abstract: Generation of cocrystals of Tavaborole (AN2690): opportunities for boron-containing APIs

Supplementary files

Article information

Article type
Paper
Submitted
14 Febr. 2017
Accepted
03 Apr. 2017
First published
03 Apr. 2017

CrystEngComm, 2017,19, 2983-2986

Generation of cocrystals of Tavaborole (AN2690): opportunities for boron-containing APIs

G. Campillo-Alvarado, C. A. Staudt, M. J. Bak and L. R. MacGillivray, CrystEngComm, 2017, 19, 2983 DOI: 10.1039/C7CE00314E

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