Issue 2, 2017

A biotinylated piperazine-rhodol derivative: a ‘turn-on’ probe for nitroreductase triggered hypoxia imaging

Abstract

We developed a nitroreductase responsive theranostic probe 1; it comprises biotinylated rhodol in conjunction with p-nitrobenzyl functionality. The probe 1 showed a remarkable fluorescence ‘turn-on’ signal in the presence of nitroreductase under physiological conditions. The probe is considerably stable within a wide biological pH range (6–8) and also is very sensitive toward a reducing micro-environment e.g. liver microsome. Further, it enables providing cellular and in vivo nematode images in a reducing microenvironment.

Graphical abstract: A biotinylated piperazine-rhodol derivative: a ‘turn-on’ probe for nitroreductase triggered hypoxia imaging

Supplementary files

Article information

Article type
Paper
Submitted
20 Sept. 2016
Accepted
30 Nov. 2016
First published
01 Dec. 2016

Analyst, 2017,142, 345-350

A biotinylated piperazine-rhodol derivative: a ‘turn-on’ probe for nitroreductase triggered hypoxia imaging

Y. Zhou, K. N. Bobba, X. W. Lv, D. Yang, N. Velusamy, J. F. Zhang and S. Bhuniya, Analyst, 2017, 142, 345 DOI: 10.1039/C6AN02107G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements