Issue 7, 2016

The synthesis of di-carboxylate esters using continuous flow vortex fluidics

Abstract

A vortex fluidic device (VFD) is effective in mediating the synthesis of di-esters at room temperature. Processing under ambient conditions allows for a simple and efficient synthesis, whilst operating under continuous flow addresses scalability. The rotational speed of the sample tube and the flow rate were critical variables during reaction optimization, and this relates to the behaviour of the fluid flow at a molecular level. Whilst at specific rotational speeds the tube imparts a vibrational response into the fluid flow, the flow rate dictates residence time and the ability to maintain high levels of shear stress. The combination of mechanically induced vibrations, rapid micromixing, high levels of shear stress and water evaporation results in yields up to 90% for 3.25 minutes or less residence time. These results are key for devising greener and more efficient processes both mediated by the VFD and other continuous flow platforms.

Graphical abstract: The synthesis of di-carboxylate esters using continuous flow vortex fluidics

Supplementary files

Article information

Article type
Paper
Submitted
16 Okt. 2015
Accepted
30 Nov. 2015
First published
01 Dec. 2015

Green Chem., 2016,18, 2193-2200

Author version available

The synthesis of di-carboxylate esters using continuous flow vortex fluidics

J. Britton, S. B. Dalziel and C. L. Raston, Green Chem., 2016, 18, 2193 DOI: 10.1039/C5GC02494C

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