Issue 9, 2016

Isoniazid cocrystallisation with dicarboxylic acids: vapochemical, mechanochemical and thermal methods

Abstract

Cocrystallisation with a series of related compounds allows for the exploration of trends and limitations set by structural differences between these compounds. In this work, we investigate how the length of a dicarboxylic acid influences the outcome of cocrystallisation with isoniazid. We have performed a systematic study on the mechanochemical, thermal and solvent vapour-assisted cocrystallisation of aliphatic dicarboxylic acids (C3–C10) with isoniazid. Our results demonstrate that the rate of mechanochemical and vapour-assisted cocrystallisation depends on the acid chain length and shows alternation between odd- and even-chain acids. The results of thermal cocrystallisation showed that the eutectic melting temperatures of isoniazid–dicarboxylic acid mixtures follow the same trend as the melting points of dicarboxylic acids.

Graphical abstract: Isoniazid cocrystallisation with dicarboxylic acids: vapochemical, mechanochemical and thermal methods

Supplementary files

Article information

Article type
Paper
Submitted
05 Sept. 2015
Accepted
27 Janv. 2016
First published
28 Janv. 2016

CrystEngComm, 2016,18, 1625-1635

Isoniazid cocrystallisation with dicarboxylic acids: vapochemical, mechanochemical and thermal methods

I. Sarceviča, A. Kons and L. Orola, CrystEngComm, 2016, 18, 1625 DOI: 10.1039/C5CE01774B

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