Issue 4, 2016

Novel synthesis of N-alkyl amines from tandem coupling of either methylamine or nitroalkane with aldehyde

Abstract

A novel tandem strategy for coupling of either methylamine or nitroalkane with aldehyde has been developed. This is the first demonstration that methylamine or nitroalkane is used as a methylation reagent, fabricating N-alkyl amines. The active Pt NWs allow for the selective preparation of a series of N-alkyl amines with good to excellent yields under mild and environmentally friendly conditions.

Graphical abstract: Novel synthesis of N-alkyl amines from tandem coupling of either methylamine or nitroalkane with aldehyde

Supplementary files

Article information

Article type
Communication
Submitted
17 Sept. 2015
Accepted
05 Nov. 2015
First published
05 Nov. 2015

Chem. Commun., 2016,52, 760-763

Novel synthesis of N-alkyl amines from tandem coupling of either methylamine or nitroalkane with aldehyde

S. Lu, J. Peng, J. Wu, C. Li, X. Cao and H. Gu, Chem. Commun., 2016, 52, 760 DOI: 10.1039/C5CC07807E

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