Issue 5, 2016

A strategy for enhanced antibacterial activity against Staphylococcus aureus by the assembly of alamethicin with a thermo-sensitive polymeric carrier

Abstract

We demonstrate here a strategy for enhanced antibacterial activity against microbial strains by the assembly of antimicrobial peptides with a temperature-responsive polymeric carrier. The assembly complex was less toxic to human cells and more stable to enzymatic cleavage. This work may provide a promising drug delivery system for antimicrobial peptides.

Graphical abstract: A strategy for enhanced antibacterial activity against Staphylococcus aureus by the assembly of alamethicin with a thermo-sensitive polymeric carrier

Supplementary files

Article information

Article type
Communication
Submitted
21 Aug. 2015
Accepted
04 Nov. 2015
First published
09 Nov. 2015

Chem. Commun., 2016,52, 896-899

A strategy for enhanced antibacterial activity against Staphylococcus aureus by the assembly of alamethicin with a thermo-sensitive polymeric carrier

P. Dong, Y. Zhou, W. He and D. Hua, Chem. Commun., 2016, 52, 896 DOI: 10.1039/C5CC07054F

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