Issue 11, 2009

Synthesis and evaluation of 2,5-dihydrochorismate analogues as inhibitors of the chorismate-utilising enzymes

Abstract

A library of 2,5-dihydrochorismate analogues were designed as inhibitors of the chorismate-utilising enzymes including anthranilate synthase, isochorismate synthase, salicylate synthase and 4-amino-4-deoxychorismate synthase. The inhibitors were synthesised in seven or eight steps from shikimic acid, sourced from star anise. The compounds exhibited moderate but differential inhibition against the four chorismate-utilising enzymes.

Graphical abstract: Synthesis and evaluation of 2,5-dihydrochorismate analogues as inhibitors of the chorismate-utilising enzymes

Supplementary files

Article information

Article type
Paper
Submitted
27 Janv. 2009
Accepted
06 Marts 2009
First published
02 Apr. 2009

Org. Biomol. Chem., 2009,7, 2421-2429

Synthesis and evaluation of 2,5-dihydrochorismate analogues as inhibitors of the chorismate-utilising enzymes

R. J. Payne, E. M. M. Bulloch, M. M. Toscano, M. A. Jones, O. Kerbarh and C. Abell, Org. Biomol. Chem., 2009, 7, 2421 DOI: 10.1039/B901694E

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