Issue 48, 2008

Disulfide-cross-linked PEG-poly(amino acid)s copolymer micelles for glutathione-mediated intracellular drug delivery

Abstract

We report biocompatible, cell-permeable core–shell–corona polymer micelles bearing glutathione-cleavable shell cross-links, which allow the facilitated release of entrapped anticancer drugs at cytoplasm in response to an intracellular glutathione level.

Graphical abstract: Disulfide-cross-linked PEG-poly(amino acid)s copolymer micelles for glutathione-mediated intracellular drug delivery

Supplementary files

Article information

Article type
Communication
Submitted
11 Sept. 2008
Accepted
28 Okt. 2008
First published
12 Nov. 2008

Chem. Commun., 2008, 6570-6572

Disulfide-cross-linked PEG-poly(amino acid)s copolymer micelles for glutathione-mediated intracellular drug delivery

A. N. Koo, H. J. Lee, S. E. Kim, J. H. Chang, C. Park, C. Kim, J. H. Park and S. C. Lee, Chem. Commun., 2008, 6570 DOI: 10.1039/B815918A

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