Issue 11, 2024

Injectable polyoxazoline grafted hyaluronic acid thermoresponsive hydrogels for biomedical applications

Abstract

Injectable thermosensitive hydrogels based on hyaluronic acid (HA) grafted with lower critical solution temperature (LCST) polyoxazoline (copolymers of poly(isopropyl-co-butyl oxazoline)) or P(iPrOx-co-BuOx) have been elaborated with tunable solution/gel temperature transitions and gel state elastic modulus. A suitable HA-g-P(iPrOx-co-BuOx-67/33)-0.10 sample with an iPrOx/BuOx ratio of 67/33, a polymerization degree (DP) of 25, a substitution degree (DS) of 10%, and displaying thermally induced gelling character with elastic (G′) and viscous (G′′) moduli crossover points at 25 °C and a G′ at 37 °C around 80 Pa has been chosen for medical application. Hydrogels obtained with HA-g-P(iPrOx-co-BuOx-67/33)-0.10 exhibited high stability at 37 °C and excellent injectability properties with full and quick reversibility. The incorporation of a secondary network (HA), until 35 wt%, into the thermosensitive hydrogel also demonstrated very good stability and injectability.

Graphical abstract: Injectable polyoxazoline grafted hyaluronic acid thermoresponsive hydrogels for biomedical applications

Supplementary files

Article information

Article type
Paper
Submitted
10 Sept. 2023
Accepted
14 Febr. 2024
First published
15 Febr. 2024

J. Mater. Chem. B, 2024,12, 2807-2817

Injectable polyoxazoline grafted hyaluronic acid thermoresponsive hydrogels for biomedical applications

M. Morel, M. Madau, D. Le Cerf, V. Dulong, A. Groo, A. Malzert-Fréon and L. Picton, J. Mater. Chem. B, 2024, 12, 2807 DOI: 10.1039/D3TB02108D

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