Issue 2, 2024

Rapid investigation of the effect of binary and ternary solvent gradient mixtures on reaction outcomes using a continuous flow system

Abstract

In a continuous flow process, generating a gradient of solvent composition with time and monitoring of the reaction mixture as it leaves the reactor allows for rapid generation of reaction information against a full range of solvent mixture compositions. The methodology was developed by screening binary solvent mixtures in a SNAr reaction in which previously reported effects were efficiently reproduced. Binary and ternary solvent gradients were then applied to an imine forming reaction revealing interesting non-linear effects.

Graphical abstract: Rapid investigation of the effect of binary and ternary solvent gradient mixtures on reaction outcomes using a continuous flow system

Supplementary files

Article information

Article type
Paper
Submitted
03 Sept. 2023
Accepted
11 Okt. 2023
First published
19 Okt. 2023
This article is Open Access
Creative Commons BY license

React. Chem. Eng., 2024,9, 379-387

Rapid investigation of the effect of binary and ternary solvent gradient mixtures on reaction outcomes using a continuous flow system

D. Drelinkiewicz, T. J. A. Corrie and R. J. Whitby, React. Chem. Eng., 2024, 9, 379 DOI: 10.1039/D3RE00464C

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